Heterofunctionalized star-shaped poly(ethylene gycols) for prote

Details Heterofunctionalized star-shaped poly(ethylene gycols) for prote Heterofunctionalized star-shaped poly(ethylene gycols) for prote

1998-12-11

2000-04-04

Truong, Duc

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Treating polymer containing material or treating a solid...

528486, 528495, 528502R, 530815, 514 2, C08F 600

Patent

active

060463058

ABSTRACT:
A biocompatible, heterofunctional, star-shaped poly(ethylene glycol) is described. Methods of making the heterofunctional star-shaped poly(ethylene glycol) and using it for conjugation with proteins are also described.

REFERENCES:
Koji Yoshinga and J. Milton Harris, Effects of Coupling Chemistry on the Activity of Poly(ethylene glycol)-Modified Alkaline Phosphatase, pp. 17 to 24.
Katre et al., Proc. Natl. Acad. Sci. USA 84 pp. 1487 (1987).
Chiu et al., Bioconjugate Chem. 4 pp. 290 (1993).
Clark et al., J. Biol. Chem. 271 pp. 21969-21977 (1996).
Inada et al., Meth. Enzymology 242 pp. 65-90 (1994).
Biotechnol. Appl. Biochem. 17 pp. 115-130 (1993).
Fuke et al., J. Controlled Release 30 pp. 27-34 (1994).
Sasaki et al., Biochem. Biophys. Res. Chem. 197 pp. 287-291.
Kodera et al., Bioconjugate Chem. 5 pp. 283-286 (1994).

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