Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1991-03-01
1994-01-18
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
435 792, 436532, 530816, 560190, C12N 1106, G01N 33549, C07C 6934
Patent
active
052799557
ABSTRACT:
Heterofunctional crosslinking agents are synthesized that covalently link molecules such as enzymes, cells, proteins and nucleic acids to a plastic substrate. The agents contain a central ring structure having a hydrophobic hydrocarbon chain that binds to a plastic substrate and distal to the hydrophobic chain one or more hydrophilic chains terminating in a reactive group that covalently binds the molecule. Immobilized molecules are useful in diagnostic assays or bioreactors. A preferred heterofunctional crosslinking agent is succinyl-olivetol-N-hydroxysuccinimide having the structure: ##STR1## This agent is prepared by reacting succinic anhydride with 5-pentyl resorcinol and condensing carboxylic acid groups with N-hydroxysuccinimide.
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patent: 4808530 (1989-02-01), Means et al.
patent: 4889916 (1989-12-01), Packard et al.
patent: 5002883 (1991-03-01), Bieniarz et al.
Pegg Randall K.
Saunders Mary S.
Naff David M.
Pegg R. Kevin
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