Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-08-29
2006-08-29
Landsman, Robert (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S007100, C514S002600
Reexamination Certificate
active
07098310
ABSTRACT:
This invention provides a purified heterodimer comprising an RXR and a hormone receptor. The invention also provides a method of screening ligands for their effect on the activity of an RXR-containing hormone receptor heterodimer comprising combining the heterodimer with the ligand and determining the effect on activity. Also provided is a method of amplifying the activity of a hormone receptor comprising forming a heterodimer with another hormone receptor.
REFERENCES:
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Mangelsdorf, D.J., et al (1990) Nature 345: 224-29.
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Pfahl Magnus
Zhang Xiao-kun
Landsman Robert
Ligand Pharmaceuticals
McDermott Will & Emery LLP
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