Heterodimers of retinoid X receptors (RXRS) and other...

Details Heterodimers of retinoid X receptors (RXRS) and other... Heterodimers of retinoid X receptors (RXRS) and other...

2006-08-29

2006-08-29

Landsman, Robert (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S007100, C514S002600

Reexamination Certificate

active

07098310

ABSTRACT:
This invention provides a purified heterodimer comprising an RXR and a hormone receptor. The invention also provides a method of screening ligands for their effect on the activity of an RXR-containing hormone receptor heterodimer comprising combining the heterodimer with the ligand and determining the effect on activity. Also provided is a method of amplifying the activity of a hormone receptor comprising forming a heterodimer with another hormone receptor.

REFERENCES:
patent: 5654137 (1997-08-01), Astrom et al.
Hamada, K. et al., “H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element,”Proc. Natl. Acad. Sci. U.S.A.86:8289-8293 (1989).
Yu, V.C., et al (1991) Cell 67: 1251-66.
Mangelsdorf, D.J., et al (1990) Nature 345: 224-29.
Glass, C.K., et al (1989) Cell 59: 697-708.
Glass, C.K., et al (1990) Cell 63: 729-38.
Darling, D.S., et al. (1991) Mol. Endocrinol. 5: 73-84.

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