Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1994-03-18
1996-12-03
Walsh, Stephen G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530386, 530350, 530324, 435 691, C07K 14725, C07K 1400
Patent
active
055809618
ABSTRACT:
Disclosed is a heterodimeric T lymphocyte receptor subunit. The subunit consists of variable, joining, constant, transmembrane, and cytoplasmic regions.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor submit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes.
T cell receptor subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
REFERENCES:
Young et al. 1983. PNAS USA 80:1194-8.
Bigler et al. 1983. J. Exp. Med. 158:1000-5.
Itohara et al. 1989. PNAS USA 86:5094-8.
Galfre et al. 1981. Meth. Enzymol. 72:3-47.
Eisen Herman N.
Kranz David M.
Saito Haruo
Tonegawa Susumu
Kemmerer Elizabeth C.
Massachusetts Institute of Technology
Walsh Stephen G.
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