Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1984-10-31
1989-10-10
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 68, 435 70, 435320, 530395, 536 27, 935 12, 935 18, 935 48, C12P 2100, C12N 1500, C07K 1300, C07H 1512
Patent
active
048731900
ABSTRACT:
Disclosed is a heterodimeric T lymphocyte receptor comprising an alpha and a beta subunit. Each subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The two subunits are connected by a disulfide bond between cysteine residues located between the constant and transmembrane region.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes.
Both the T cell receptor protein and its subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
REFERENCES:
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Murre et al., NATURE, 316:549-552, 1985.
Lefranc et al., NATURE, 316:464-466, 1985.
Berzofsky et al., 1983, "Promising Clues to Reception Genes and Molecules", Immunology Today, 4, 299-301.
Fabbi et al., "Homology of Ti X-Subunit of a T-Cell Antigen-MHC Receptor with Immunoglobulin", NATURE, 312, pp. 269-271.
"Sequence Relationships Between Putative T-Cell Receptor Polypeptides and Immunoglobulins", by S. M. Hedrick et al., Nature, 308, 153-158, (1984).
"A Human T Cell-Specific cDNA Clone Encodes a Protein Having Extensive Homology to Immunoglobulin Chains", by Y. Yanagi et al., Nature, 308, 145-149, (1984).
"Complete Primary Structure of a Heterodimeric T-Cell Receptor Deduced from cDNA Sequences", by H. Saito et al., Nature, 309, 757-762, (1984).
"Isolation of cDNA Clones Encoding T Cell-Specific Membrane-Associated Proteins", by S. M. Hedrick et al., Nature, 308, 149-153, (1984).
"A Third Type of Murine T-Cell Receptor Gene", by Y-H Chein et al., Nature, 312, 31-35, (1984).
"A Third Rearranged and Expressed Gene in a Clone of Cytotoxic T Lymphocytes", by H. Saito et al., Nature, 312, 36-40, (1984).
"Structure, Expression and Divergence of T-Cell Receptor .beta.-Chain Variable Regions", by P. Patten et al., Nature, 312, 40-46, (1984).
Eisen Herman N.
Kranz David M.
Saito Haruo
Tonegawa Susumu
Massachusetts Institute of Technology
Mays Thomas D.
Wiseman Thomas G.
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