Heterodimeric T lymphocyte receptor

Details Heterodimeric T lymphocyte receptor Heterodimeric T lymphocyte receptor

1994-06-21

1999-03-16

Scheiner, Toni R.

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

436548, 435334, 4353431, 53038822, 53038875, G01N 33531, C07K 1628

Patent

active

058829458

ABSTRACT:
Disclosed is a heterodimeric T lymphocyte receptor subunit. The subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor subunit were determined using cDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes.
T cell receptor subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.

REFERENCES:
Berzofsky, Immunology Today 4: 299-301, 1983.
Haskins et al, J. Exp. Med. 157: 1149-1169, 1983.
Acuto et al. Cell 34: 717-726 Oct. 1983.
Kapler et al. Cell 34: 727-737, 1983.

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