Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides with at least one nonpeptide bond other than a...
Patent
1989-07-27
1990-11-13
Mays, Thomas D.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides with at least one nonpeptide bond other than a...
530395, 4351723, C07K 1300, C07K 1500, C12N 1500
Patent
active
049702963
ABSTRACT:
Disclosed is a heterodimeric T lymphocyte receptor comprising an alpha and a beta subunit. Each subunit consists of a signal peptide, variable, joining, constant, transmembrane, and cytoplasmic regions. The two subunits are connected by a disulfide bond between cysteine residues located between the constant and transmembrane region.
The structure, amino acid, and nucleotide sequence of the lymphocyte receptor were determined using CDNA clones derived from a functional murine cytotoxic T lymphocyte clone. The genes corresponding to these cDNA are expressed and rearranged specifically in T cells and have significant sequence homologies to immunoglobulin V and C genes.
Both the T cell receptor protein and its subunits may be produced from the cDNA clones. The protein molecules may be further used for the production of T-cell clone specific antibodies.
REFERENCES:
patent: 4713332 (1987-12-01), Mak
Eisen Herman N.
Kranz David M.
Saito Haruo
Tonegawa Susumu
Board of Trustees of Leland Stanford Jr. University
Massachusetts Institute of Technology
Mays Thomas D.
Peet Richard C.
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