Heterodimeric receptor libraries using phagemids

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S007200, C435S235100, C435S441000

Reexamination Certificate

active

07118866

ABSTRACT:
Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a filamentous phage coat protein membrane anchor domain fused to at least one of the polypeptides.

REFERENCES:
patent: 5770356 (1998-06-01), Light et al.
patent: 2086936 (1991-07-01), None
patent: 2091335 (1991-09-01), None
patent: 2095633 (1991-12-01), None
Better et al.,Escherichia coliSecretion of an Active Chimeric Antibody Fragment, 1988,Science, 240: pp. 1041-1043.
Chang et al., Expression of Antibody Fab Domains on Bacteriophage Surfaces, 1991,J. Immunol., 147: pp. 3610-3614.
Kabat et al.,Sequences of Proteins or Immunological Interest, 1987, U.S. Dept. HHS, 4thEdition pp. 494-525.
Winnacker,From Genes to Clones, 1987, VCH, Weinhein, Germany, pp. 276-279.
Winter et al., Man-made Antibodies, 1991,Nature, 349: pp. 293-299.

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