Heterodimeric receptor libraries using phagemids

Details Heterodimeric receptor libraries using phagemids Heterodimeric receptor libraries using phagemids

1994-10-12

1998-06-02

Degen, Nancy

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 71, 4351723, 4353201, 5303871, 5303873, G01N 3353, C12N 1500, C12P 2100, C07K 1600

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active

057598177

ABSTRACT:
Filamentous phage comprising a matrix of cpVIII proteins encapsulating a genome encoding first and second polypeptides of an antogenously assembling receptor, such as an antibody, and a receptor comprised of the first and second polypeptides surface-integrated into the matrix via a cpVIII membrane anchor domain fused to at least one of the polypeptides with a mutagenized CDR3 region.

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