Heterodimeric osteogenic factor

Details Heterodimeric osteogenic factor Heterodimeric osteogenic factor

1994-08-29

1996-04-16

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514953, 424423, 424484, 424486, 623 16, A61K 3818, A61F 228

Patent

active

055082637

ABSTRACT:
The present invention provides osteogenically active protein preparations comprising a heterodimer of P3 OF 31-34 subunit B and P3 OF 31-34 subunit D, which subunits are linked with at least one disulfide bond and methods for their preparation. The invention further provides cell lines transformed with nucleotide sequences encoding P3 OF 31-34 subunit B and P3 OF 31-34 subunit D and vectors comprising those sequences in operative association with an expression control sequence.

REFERENCES:
patent: 3458397 (1969-07-01), Meyers et al.
patent: 4294753 (1981-10-01), Urist
patent: 4314380 (1982-02-01), Miyata et al.
patent: 4394370 (1983-07-01), Jefferies
patent: 4407787 (1983-10-01), Stemberger
patent: 4430760 (1984-02-01), Smestad
patent: 4434094 (1984-02-01), Seysdin et al.
patent: 4440750 (1984-04-01), Glowacki et al.
patent: 4455256 (1984-06-01), Urist
patent: 4488911 (1984-12-01), Luck et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4619989 (1986-10-01), Urist
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4681763 (1987-07-01), Nathanson et al.
patent: 4713076 (1987-12-01), Draenert
patent: 4725536 (1988-02-01), Fritsch et al.
patent: 4734363 (1988-03-01), Dattagupta et al.
patent: 4757006 (1988-07-01), Toole, Jr. et al.
patent: 4761471 (1988-08-01), Urist
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4789732 (1988-12-01), Urist
patent: 4804744 (1989-02-01), Sen
patent: 4828563 (1989-05-01), Muller-Lierheim
patent: 4863899 (1989-09-01), Todaro
patent: 4877864 (1989-10-01), Wang et al.
patent: 4952404 (1990-08-01), Vallee et al.
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5001169 (1991-03-01), Nathan et al.
patent: 5002770 (1988-08-01), Kuberasampath et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5017486 (1991-05-01), Sawai et al.
patent: 5084050 (1992-01-01), Draenert
patent: 5106748 (1992-04-01), Wozney et al.
patent: 5108922 (1992-04-01), Wang et al.
patent: 5116738 (1992-05-01), Wang et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5166058 (1992-11-01), Wang et al.
patent: 5168050 (1992-12-01), Hammonds, Jr. et al.
patent: 5182365 (1993-01-01), Oppermann et al.
patent: 5187076 (1993-02-01), Wozney et al.
Amitani and Nakata, "Studies on a Factor Responsible for New Bone Formation from Osteosarcoma in Mice", Calcif. Tiss. Res., 17:139-150 (1975).
"Australian institutes join to develop bio-products", Biotechnology Newswatch, 9(23):1-3 (Dec. 4, 1989).
Assoian et al., "Transforming Growth Factor-.beta. in Human Platelets", J. Biol. Chem., 285(11):7155-7160 (Jun. 10, 1983).
Balland et al., "Use of synthetic oligonucleotides in gene isolation and manipulation", Biochimie, 67:725-736 (1985).
Bauer and Urist, "Human Osteosarcoma-Derived Soluble Bone Morphogenetic Protein", Clin. Ortho. & Rel. Res., 154:291-295 (Jan.-Feb. 1981).
Baylink and Liu, "The Regulation of Endosteal Bone Volume", J. Periodontal., 1:43-49 (1979).
Bentz et al., "Amino Acid Sequence of Bovine Osteoinductive Factor", J. Biol. Chem., 265(9):5024-5029 (Mar. 25, 1990).
Bentz et al., "Purification and Characterization of a Unique Osteoinductive Factor From Bovine Bone", J. Bone and Mineral Res., 4(Supplement 1):S280, No. 650 (1989).
Bentz et al., "Purification of an Osteoinductive Factor From Bovine Demineralized Bone", J. Cell. Biol., 107:162a, No. 918 (1989).
Bitter and Egan, "Expression of heterologous genes in Saccharomyces cerevisiae from vectors utilizing the glyceralde-hyde-3-phosphate dehydrogenase gene promoter", Gene, 32:263-274 (1984).
Celeste et al., "Identification of transforming growth factor .beta. family members present in bone-inductive protein purified from bovine bone", Proc. Natl. Acad. Sci. USA, 87:9843-9847 (Dec. 1990).
Cepko et al., "Construction and applications of a Highly Transmissible Murine Retrovirus Shuttle Vector", Cell, 37:1053-1062 (Jul. 1984).
Conover and Urist, "Dentin Matrix Bone Morphogenetic Protein", in The Chemistry and Biology of Mineralized Connective Tissues, pp. 597-606, (Veis ed., Elsevier) (1981).
Drivdahl et al., "Regulation of DNA Synthesis in Chick Calvaria Cells by Factors from Bone Organ Culture", Proc. Soc. Exp. Biol. Med., 168:143-150 (1981).
Edge et al., "Total synthesis of a human leukocyte interferon gene", Nature, 292:756-762 (Aug. 20, 1981).
Farley and Baylink, "Purification of a Skeletal Growth Factor from Human Bone", Biochemistry, 21(14):3502-3507 (1982).
Farley et al., "Human Skeletal Growth Factor: Characterization of the Mitogenic Effect on Bone Cells in Vitro", Biochemistry, 21(14):3508-3513 (1982).
Gorman et al., "Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells", Mol. Cell. Biol., 2(9):1044-1051 (Sep. 1982).
Hanamura et al., "Solubilization and Purification of Bone Morphogenetic Protein (BMP) from Dunn Osteosarcoma", Clin. Ortho. & Rel. Res., 153:232-240 (Nov.-Dec. 1980).
Hanamura et al., "Solubilized Bone Morphogenetic Protein (BMP) from Mouse Osteosarcoma and Rat Demineralized Bone Matrix", Clin. Ortho. & Rel. Res., 148:281-290 (May 1980).
Harakas, "Demineralized Bone-Matrix-Induced Osteogenesis", Clin. Ortho. Rel. & Res, 188:239-251 (Sep. 1984).
Hauschka et al., "Direct identification of the calcium-binding amino acid, .gamma.-carboxyglutamate, in mineralized tissue", Proc. Natl. Acad. Sci. USA, 72(10:3925-3929 (Oct. 1975).
Howard et al., "Evidence for the Coupling of Bone Formation to Bone Resorption in Vitro", Metab. Bone Dis. & Rel. Res., 2:131-135 (Oct. 1980).
Israel et al., "Expression of Recombinant BMP2 in Chinese Hamster Ovary Cells", J. Cell. Biochem., Suppl. 15F:168, Abstract No. Q 111 (1991).
Luyten et al., "Purification and Partial Amino Acid Sequence of Osteogenin, a Protein Initiating Bone Differentiation", J. Biol. Chem., 264(23):13377-13380 (Aug. 15, 1989).
Lyons et al., "Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor .beta. gene superfamily", Proc. Natl. Acad. Sci. USA, 86:4554-4558 (Jun. 1989).
Maugh, "Human Skeletal Growth Factor Isolated", Science, 217:819 (Aug. 1982).
Mbuyi et al., "Plasma Proteins in Human Cortical Bone: Enrichment of .alpha..sub.2 HS-Glyprotein, .alpha..sub.1 Acid-Glycoprotein, and IgE", Calcif. Tissue Int., 34:299-231 (1982).
Mizutani and Urist, "The Nature of Bone Morphogenetic Protein (BMP) Fractions Derived from Bovine Bone Matrix Gelatin", Clin. Ortho. & Rel. Res., 171:213-223 (Nov.-Dec. 1982).
Nogami et al., "Radioactive Isotope Labeled Diffusible Components of a Bone Morphogenetic Substratum", Clin. Ortho. & Rel. Res., 122:307-314 (Jan.-Feb. 1977).
Ozkaynak et al., "OP-1 cDNA encodes an osteogenic protein in the TGF-.beta. family", EMBO J., 9(7):2085-2093 (1990).
Price et al., "Characterization of a .gamma.-carboxyglutamic acid-containing protein from bone", Proc. Natl. Acad. Sci. USA, 73(5):1447-1451 (May 1976).
Raisz and Kream, "Regulation of Bone Formation, (First of Two Parts)", New England J. Med., 309(1):29-35 (Jul. 7, 1983).
Raisz and Kream, "Regulation of Bone Formation, (Second of Two Parts)", New England J. Med., 309(2):83-89 (Jul. 14, 1983).
Reddi, "Cell Biology and Biochemistry of Endochondral Bone Development", Coll. Res., 1:209-226 (1981).
Sampath and Reddi, "Homology of bone-inductive proteins from human, monkey, bovine, and rat extracellular matrix", Proc. Natl. Acad. Sci. USA, 80:6591-6595 (Nov. 1983).
Sampath et al., "Bovine Osteogenic Protein Is Composed of Dimers of OP-1 and BMP-2A, Two Members of the Transforming Growth Factor-.beta. Superfamily", J. Biol. Chem., 265(22):13198-13205 (Aug. 5, 1990).
Sen et al., "Purification and Partial Characterization of a Novel Osteogenic Protein", in Development and Diseases of Cartilage and Bone Matrix, pp. 201-220 (Alan R. Liss, Inc.) (1987).
Seyedin et al., "Purification and characterization of two cartilage-inducing factors from bov

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