Heterodimeric fusion proteins useful for targeted immune...

Details Heterodimeric fusion proteins useful for targeted immune... Heterodimeric fusion proteins useful for targeted immune...

2007-05-21

2009-08-18

Mertz, Prema (Department: 1646)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S252300, C435S325000, C435S320100

Reexamination Certificate

active

07576193

ABSTRACT:
Disclosed are methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12. In order to insure that the proper ratio of fused and non-fused subunits are obtained in the fusion protein, a specific stepwise approach to genetic engineering is used. This consists of first expressing the non-fused p40 IL-12 subunit in a production cell line, followed by or simultaneously expressing in the same cell, a second recombinant fusion protein consisting of the fused polypeptide linked by a peptide bond to the p35 subunit of IL-12. Molecules containing the p35 fusion protein cannot be secreted from the transfected mammalian cell without first complexing in a one to one ratio with the p40 subunit, thus ensuring the production of active heterodimeric fusion proteins.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4469797 (1984-09-01), Albarella
patent: 4676980 (1987-06-01), Segal et al.
patent: 4703008 (1987-10-01), Lin
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4975369 (1990-12-01), Beavers et al.
patent: 5019368 (1991-05-01), Epstein et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5082658 (1992-01-01), Palladino
patent: 5091513 (1992-02-01), Huston et al.
patent: 5114711 (1992-05-01), Bell et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5225538 (1993-07-01), Capon et al.
patent: 5225539 (1993-07-01), Winter et al.
patent: 5258498 (1993-11-01), Huston et al.
patent: 5314995 (1994-05-01), Fell, Jr. et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5359035 (1994-10-01), Habermann et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5428130 (1995-06-01), Capon et al.
patent: 5441868 (1995-08-01), Lin
patent: 5457038 (1995-10-01), Trinchieri et al.
patent: 5480981 (1996-01-01), Goodwin et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5541087 (1996-07-01), Lo et al.
patent: 5543297 (1996-08-01), Cromlish et al.
patent: 5547933 (1996-08-01), Lin
patent: 5552524 (1996-09-01), Basinski et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5601819 (1997-02-01), Wong et al.
patent: 5609846 (1997-03-01), Goldenberg
patent: 5614184 (1997-03-01), Sytkowski et al.
patent: 5618698 (1997-04-01), Lin
patent: 5624821 (1997-04-01), Winter et al.
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5645835 (1997-07-01), Fell, Jr. et al.
patent: 5650150 (1997-07-01), Gillies
patent: 5650492 (1997-07-01), Gately et al.
patent: 5667776 (1997-09-01), Zimmerman et al.
patent: 5679543 (1997-10-01), Lawlis
patent: 5688679 (1997-11-01), Powell
patent: 5691309 (1997-11-01), Basinski et al.
patent: 5709859 (1998-01-01), Aruffo et al.
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: 5719266 (1998-02-01), DiMarchi et al.
patent: 5723125 (1998-03-01), Chang et al.
patent: 5726044 (1998-03-01), Lo et al.
patent: 5728552 (1998-03-01), Fujisawa et al.
patent: 5733876 (1998-03-01), O'Reilly et al.
patent: 5756349 (1998-05-01), Lin
patent: 5756461 (1998-05-01), Stephens
patent: 5759551 (1998-06-01), Ladd et al.
patent: 5770195 (1998-06-01), Hudziak et al.
patent: 5800810 (1998-09-01), Doyle et al.
patent: 5807715 (1998-09-01), Morrison et al.
patent: 5827516 (1998-10-01), Urban et al.
patent: 5827703 (1998-10-01), Debs et al.
patent: 5837682 (1998-11-01), Folkman et al.
patent: 5837821 (1998-11-01), Wu
patent: 5843423 (1998-12-01), Lyman et al.
patent: 5854205 (1998-12-01), O'Reilly et al.
patent: 5856298 (1999-01-01), Strickland
patent: 5858347 (1999-01-01), Bauer et al.
patent: 5885795 (1999-03-01), O'Reilly et al.
patent: 5886178 (1999-03-01), Allen et al.
patent: 5888772 (1999-03-01), Okasinski et al.
patent: 5888773 (1999-03-01), Jost et al.
patent: 5891680 (1999-04-01), Lieschke et al.
patent: 5908626 (1999-06-01), Chang et al.
patent: 5922685 (1999-07-01), Rakhmilevich et al.
patent: 5955422 (1999-09-01), Lin
patent: 5994104 (1999-11-01), Anderson et al.
patent: 5994126 (1999-11-01), Steinman et al.
patent: 6080409 (2000-06-01), Laus et al.
patent: 6086875 (2000-07-01), Blumberg et al.
patent: 6100387 (2000-08-01), Herrmann et al.
patent: 6169070 (2001-01-01), Chen et al.
patent: 6171588 (2001-01-01), Carron et al.
patent: 6231536 (2001-05-01), Lentz
patent: 6277375 (2001-08-01), Ward
patent: 6284536 (2001-09-01), Morrison et al.
patent: 6291158 (2001-09-01), Winter et al.
patent: 6335176 (2002-01-01), Inglese et al.
patent: 6340742 (2002-01-01), Burg et al.
patent: 6348192 (2002-02-01), Chan et al.
patent: 6406689 (2002-06-01), Falkenberg et al.
patent: 6429199 (2002-08-01), Krieg et al.
patent: 6444792 (2002-09-01), Gray et al.
patent: 6475717 (2002-11-01), Enssle et al.
patent: 6485726 (2002-11-01), Blumberg et al.
patent: 6500641 (2002-12-01), Chen et al.
patent: 6506405 (2003-01-01), Desai et al.
patent: 6551592 (2003-04-01), Lindhofer et al.
patent: 6583272 (2003-06-01), Bailon
patent: 6586398 (2003-07-01), Kinstler et al.
patent: 6617135 (2003-09-01), Gillies et al.
patent: 6620413 (2003-09-01), DeSauvage et al.
patent: 6627615 (2003-09-01), Debs et al.
patent: 6646113 (2003-11-01), Dreyfuss et al.
patent: 6750329 (2004-06-01), Rosenblum et al.
patent: 6838260 (2005-01-01), Gillies et al.
patent: 7141151 (2006-11-01), Habets et al.
patent: 7226998 (2007-06-01), Gillies et al.
patent: 2001/0053539 (2001-12-01), Lauffer et al.
patent: 2002/0037558 (2002-03-01), Lo et al.
patent: 2002/0081664 (2002-06-01), Lo et al.
patent: 2002/0142374 (2002-10-01), Gallo et al.
patent: 2002/0146388 (2002-10-01), Gillies
patent: 2002/0147311 (2002-10-01), Gillies et al.
patent: 2002/0192222 (2002-12-01), Blumberg et al.
patent: 2002/0193570 (2002-12-01), Gillies et al.
patent: 2003/0003529 (2003-01-01), Bayer
patent: 2003/0012789 (2003-01-01), Blumberg et al.
patent: 2003/0044423 (2003-03-01), Gillies et al.
patent: 2003/0049227 (2003-03-01), Gillies et al.
patent: 2003/0105294 (2003-06-01), Gillies et al.
patent: 2003/0139365 (2003-07-01), Lo et al.
patent: 2003/0139575 (2003-07-01), Gillies
patent: 2003/0157054 (2003-08-01), Gillies et al.
patent: 2003/0166163 (2003-09-01), Gillies
patent: 2003/0166877 (2003-09-01), Gillies et al.
patent: 2004/0013640 (2004-01-01), Zardi et al.
patent: 2004/0033210 (2004-02-01), Gillies
patent: 2004/0043457 (2004-03-01), Schumacher et al.
patent: 2004/0053366 (2004-03-01), Lo et al.
patent: 2004/0072299 (2004-04-01), Gillies et al.
patent: 2004/0082039 (2004-04-01), Gillies et al.
patent: 2004/0180035 (2004-09-01), Gillies
patent: 2004/0180386 (2004-09-01), Carr et al.
patent: 2004/0203100 (2004-10-01), Gillies et al.
patent: 2005/0069521 (2005-03-01), Gillies et al.
patent: 2172588 (1989-03-01), None
patent: 93100115.3 (1993-07-01), None
patent: 931001153 (1993-07-01), None
patent: 3712985 (1988-11-01), None
patent: 0158198 (1985-10-01), None
patent: 0211769 (1987-02-01), None
patent: 0237019 (1987-09-01), None
patent: 0256714 (1988-02-01), None
patent: 0294703 (1988-12-01), None
patent: 0308936 (1989-03-01), None
patent: 0314317 (1989-05-01), None
patent: 0318554 (1989-06-01), None
patent: 0319012 (1989-06-01), None
patent: 0326120 (1989-08-01), None
patent: 0344134 (1989-11-01), None
patent: 0350230 (1990-01-01), None
patent: 0375562 (1990-06-01), None
patent: 0428596 (1991-05-01), None
patent: 0433827 (1991-06-01), None
patent: 0439095 (1991-07-01), None
patent: 0511747 (1992-11-01), None
patent: 0519596 (1992-12-01), None
patent: 0601043 (1994-06-01), None
patent: 0640619 (1995-03-01), None
patent: 0668353 (1995-08-01), None
patent: 0699755 (1996-03-01), None
patent: 0706799 (1996-04-01), None
patent: 0790309 (1997-08-01), None
patent: 0396387 (1999-11-01), None
patent: 1088888 (2001-04-01), None
patent: 2188638 (1987-10-01), None
patent: 2292382 (1996-02-01), None
patent: 63267278 (1988-11-01), None
patent: 63267296 (1988-11-01), None
patent: 3712985 (2003-09-01), None
patent: WO-8601533 (1986-03-01), None
patent: WO-8800052 (1988-01-01), None
patent: WO-8809344 (1988-12-01), None
patent: WO-8902922 (1989-04-01), None
patent: WO-8909620 (1989-10-01), None
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