Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2007-03-27
2007-03-27
Mertz, Prema (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
C530S402000, C536S023400, C435S326000, C435S252300, C435S254110, C435S320100
Reexamination Certificate
active
11486758
ABSTRACT:
Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka L-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
REFERENCES:
patent: 6531576 (2003-03-01), Piddington et al.
patent: 2004/0059095 (2004-03-01), Piddington et al.
Incyte Pharmaceuticals, Inc. EST, INC1209538, 1996.
Incyte Pharmaceuticals, Inc. EST, INC1209224, 1996.
Genbank Acc. No. AA501097, EST1145727, 1997.
Incyte Pharmaceuticals, Inc. Library, BRAITUT24, date unknown.
Incyte Pharmaceuticals, Inc. EST, INC3347129, 1997.
Genbank Acc. No. AI045195, EST1784567, 1998.
Incyte Pharmaceuticals, Inc. Library, TESTNOT11, date unknown.
Incyte Pharmaceuticals, Inc. EST, INC4922572, 1998.
Incyte Pharmaceuticals, Inc. EST, INC4883838H2, 1998.
Incyte Pharmaceuticals, Inc. Library, LUNLTMT01, date unknown.
Incyte Pharmaceuticals, Inc. EST, INC4883096, 1998.
Genbank Acc. No. AW482402, EST3893275, 2000.
Incyte Pharmaceuticals, Inc. EST, INC7081907, 2000.
Bowie et al., “Deciphering the message in protein sequences: tolerance to amino acid substitutions,”Science 247(4948): 1306-1310, 1990.
Ngo et al., “In the Protein Folding Problem and Tertiary Structure Prediction,” Merz and Le Grand (eds), Springer Verlag, pp. 433 and 492-1495, 1994.
Tannheimer Stacey
West James W.
Mertz Prema
Sawislak Deborah A.
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