Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1987-01-30
1990-06-05
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530300, 530380, 530356, 530827, 530829, 530840, 530350, 514885, 514886, 514921, C07K 1300, A61K 3724
Patent
active
049315480
ABSTRACT:
A polypeptide transforming growth factor found in porcine platelets, having activity in the TGF-.beta. assay and a molecular weight of about 25 kDa. The factor is a heterodimer, one chain of which has an N-terminal sequence very different from human platelet TGF-.beta., and the other chain of which has an N-terminal sequence identical to that of human platelet TGF-.beta.. The factor is purified using gel filtration and reverse phase HPLC.
REFERENCES:
patent: 4434094 (1984-02-01), Seyedin et al.
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4627982 (1986-12-01), Seyedin et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4806523 (1989-02-01), Bentz et al.
Assdian et al., JBC 258, 1983, pp. 7155-7160.
Wahl et al., PNAS, 84, 1987, pp. 5788-5792.
Seyedin et al., JBC 261, 1986, pp. 5693-5695.
Roberts et al., Biochemistry 22(25), 1983, pp. 5692-5698.
Marquarilt et al., Science 223, 1984. pp. 1079-1081.
Childs et al., PNAS 79, 1982, 5312-5316.
Sporn et al., Science 219, 1983, pp. 1329-1320.
Derynik et al., JBC 261, 1986, pp. 4377-4379.
"Heterodimeric Transforming Growth Factor Beta-Biological Properties and Interaction with Tree Types of Cell Surface Receptors", Cheifetz, et al., Journal of Biological Chemistry, vol. 263, Aug. 5, 1988, pp. 10783-10789.
Trends in Biochem. Sci., vol. 10, pp. 239-240. (1985), J. Massague, "The Transforming Growth Factors".
Science, vol. 233, pp. 532-534 (1986), M. B. Sporn, et al; "Transforming Growth Factor-beta: Biological Function and Chemical Structure".
J. of Biol. Chem., vol. 261, pp. 5693-5695 (May 5, 1986), S. Seyedin; "Cartilage-Inducing Factor-A: Apparent Identity to Transforming Growth Factor-Beta".
Proc. Natl. Acad. Sci. USA, vol. 82, pp. 2267-2271 (April 1985), S. Seyedin, et al.; "Purification and Characterization of Two Cartilage-Inducing Factors from Bovine Demineralized Bone".
Collagen Corporation Annual Report, 1987.
Collagen Corporation, 10 pages.
J. of Biol. Chem., vol. 261, pp. 9972-9978 (Jul. 25, 1986); S. Chelfetz et al.; "Cellular Distribution of Type I and Type II Receptors for Transforming Growth Factor-Beta".
Cell, vol. 48, pp. 409-414 (Feb. 13, 1987); S. Cheifetz, et al.; "The Transforming Growth Factor-Beta System, a Complex Pattern of Cross-Reactive Ligands and Receptors".
Biochemistry, vol. 22 (1983), "Purification and Properties of Type .beta. Transforming Growth Factor from Bovine Kidney" (Roberts), pp. 5692-5698.
J. Biol. Chem., vol. 256 (Jun. 1983), "Transforming Growth Factor-.beta.-In Human Platelets", (Assoian), pp. 7155-7160.
Lucas Roger C.
Tsang Monica L.-S.
Weatherbee James A.
Bauman Mary P.
Draper Garnette D.
Haller James R.
Kaihoi Gregory P.
Techne Corporation
LandOfFree
Heterodimer form of transforming growth factor-beta does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Heterodimer form of transforming growth factor-beta, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterodimer form of transforming growth factor-beta will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-492291