Heterocyclymethylamino derivatives of cyclobutene-3,4-diones

Details Heterocyclymethylamino derivatives of cyclobutene-3,4-diones Heterocyclymethylamino derivatives of cyclobutene-3,4-diones

1997-06-10

1999-02-16

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514469, 546334, 544335, 549467, A61K 3134, A61K 3144, C07D30781, C07D21350

Patent

active

058721398

ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, straight chain alkyl, branched chain alkyl, cycloalkyl, bicycloalkyl or aralkyl, wherein the aromatic moiety of the aralkyl group may be optionally substituted with one to three straight chain alkyl, halogen, nitro, cyano, alkoxy, alkoxycarbonyl, trifluoromethyl or trifluoromethoxy groups; R.sub.3 is hydrogen, formyl, alkanoyl, alkenoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is selected from the group consisting of: ##STR2## wherein n is 0 or 1; R.sub.4, R.sub.5 and R.sub.6 are, independently, cyano, nitro, amino, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, alkylamino, dialkylamino, sulfamyl, alkylsulfonamido, arylsulfonamido, alkylcarboxamido, arylcarboxamido, alkanoyl, alkylsulfonyl, perfluoroalkylsulfonyl, arylsulfonyl, chloro, bromo, fluoro, iodo, 1-imidazolyl, carboxyl or hydrogen; or a pharmaceutically acceptable salt thereof, relax smooth muscles.

REFERENCES:
patent: 4390701 (1983-06-01), Algieri et al.
patent: 4673747 (1987-06-01), Nobara et al.
patent: 5354746 (1994-10-01), Chandrakumar et al.
patent: 5397790 (1995-03-01), Butera et al.
patent: 5401753 (1995-03-01), Butera et al.
patent: 5403853 (1995-04-01), Butera et al.
patent: 5403854 (1995-04-01), Butera et al.
patent: 5464867 (1995-11-01), Antane et al.
patent: 5466712 (1995-11-01), Butera et al.
Tietze et al., Chem. Berg., 1991, 124, 1215-1221.
Tietze et al., Bioconjugate Chem., 1991, 2, 148-153.
Ehrhardt et al., Chem. Ber., 1977, 110, 2506-2523.
Neuse et al., Liebigs Ann. Chem., 1973, 619-632.
Takeno et al. Public Patent Disclosure Bull. No. 6-92915 (Japan), (1994).

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