Heterocyclyls as selective melanin concentrating hormone...

Details Heterocyclyls as selective melanin concentrating hormone... Heterocyclyls as selective melanin concentrating hormone...

2008-04-22

2008-04-22

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S131000, C548S204000, C548S236000, C548S255000, C548S267600, C548S338100, C548S375100, C548S561000, C549S076000, C549S496000

Reexamination Certificate

active

11181255

ABSTRACT:
The present invention discloses compounds of formula Iwherein m, n, p, R1, R2and X, are herein defined, the compounds being novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

REFERENCES:
patent: 2001/0049373 (2001-12-01), Chalquest
Sawa, et al.; Recent developments in the design of orally bioavailable beta3-adrenergic receptor agonists. 2006; Current Medicinal Chemistry; 13, 25-37.
Orbach, S; Drug-drug interactions: an important negative attribute in drugs. 2003, Drugs of Today, 39, 301-338.

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