Heterocyclylcarbonyl substituted benzofuranyl-ureas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514365, 514444, 5462841, 544333, 548200, C07D40506, A61K 3144

Patent

active

059227400

ABSTRACT:
Heterocyclyclcarbonyl substituted benzofuranyl-ureas are prepared by reacting heterocyclylcarbonyl substituted 3-amino-benzofuranes with appropriate isocyanates or isothiocyanates. The unsubstituted ureas are transferred into substituted ureas by usual methods of substitution. The heterocyclylcarbonyl substituted benzofuranyl-ureas are useful as active ingredients in medicaments particularly for the treatment of acute and chronical inflammatory processes.

REFERENCES:
patent: 4745127 (1988-05-01), Atkinson et al.
Biochem.J. 291, 389-395 (1993).
Biochem.Pharmacol. 42, 153-162 (1991).
Eur.J.Pharmacol. 127, 105-115, 1986.

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