Heterocyclyl-2-propyn-1-amines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514445, 514448, 514471, 549 62, 549 64, 549 65, 549 71, 549 74, 549475, 549476, 549478, 549484, 549485, 549486, 549491, A61K 3138, A61K 3134, C07D33312, C07D30702

Patent

active

047436174

ABSTRACT:
This invention relates to novel heterocyclyl-2-propyn-1-amines which are useful as dopamine beta hydroxylase inhibitors in the treatment of hypertension.

REFERENCES:
patent: 3211741 (1965-10-01), Martin et al.
patent: 4128561 (1978-12-01), Braye
Padgett, S. R., Wimalasena, K., Herman, H. H. Sirimanne, S. R., and May, S. W., Biochemistry, 24, 5826-5839, 1985.
Colombo, G. and Villafranca, J., J. Biol. Chem. 259(24), 15017-15020, 1984.

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