Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-04-13
1978-08-08
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602948D, 2602948F, 2602948H, 548336, 424273R, C07D41702, C07D40302, A61K 3144
Patent
active
041057708
ABSTRACT:
The compounds are heterocyclomethylsulphinylethyl derivatives of N-cyanoguanidines, thioureas and 2-amino-1-nitroethylene which are histamine H.sub.2 -antagonists or are converted into histamine H.sub.2 -antagonists in the animal body. Two specific compounds of the present invention are 1-nitro-2-[2-((2-thiazolyl)methylsulphinyl)ethylamino]-2-[2-((2-thiazolyl) methylthio)ethylamino]ethylene and 1-nitro-2,2-bis-[2-((2-thiazolyl)methylsulphinyl)ethylamino]ethylene.
REFERENCES:
patent: 3968227 (1976-07-01), Durant et al.
patent: 3979398 (1976-09-01), White
patent: 4025527 (1977-05-01), Durant et al.
Durant Graham J.
Ganellin Charon R.
Hesselbo Torben
White George R.
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Rotman Alan L.
Smith Kline & French Laboratories Limited
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