Heterocyclically substituted cycloalkano[b]-indolesulphonamides

Details Heterocyclically substituted cycloalkano[b]-indolesulphonamides Heterocyclically substituted cycloalkano[b]-indolesulphonamides

1991-08-23

1993-06-29

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514411, 514381, 514382, 514406, 514256, 514269, 514274, 514307, 514309, 514310, 514311, 514312, 514313, 514314, 514259, 514260, 514249, 514248, 514365, 514369, 514370, 514367, 514372, 514373, 514374, 514376, 514377, 514375, 514378, 514380, 514397, 514394, 514395, 5142328, 514323, 514253, 514254, 544372, 544142, 544237, 544235, 544353, 544354, 544355, 544356, 544284, 544298, 544333, 544322, 544405, 544238, 548439, 548449, 548448, 548450, 548451, 548252, 548253, 548251, 548181, 548159, 548214, 548207, 548212,

Patent

active

052235173

ABSTRACT:
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or amidation, or by reaction of heterocyclically substituted hydrazines with cycloalkanones or by subsequent introduction of the heterocyclic group into appropriate indole derivatives. The heterocyclically substituted cycloalkano[b]-indolesulphonamides can be employed for the treatment of thromboembolic disorders, ischaemias, arteriosclerosis, asthma, allergies and for the prophylaxis of myocardial infarcts.

REFERENCES:
patent: 4988820 (1991-01-01), Boshagen et al.
Okawa et al., Chemical Abstracts vol. 69, Entry 37117u (1968).
Hahn et al., Chemical Abstracts, vol. 85, entry 94224f (1976).
Boeshagen et al., Chemical Abstracts, vol. 109, entry 230800j (1988).

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