Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1981-06-11
1983-09-20
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544238, 544296, 544357, 548127, 548128, 548130, 548135, 548134, 548136, C07D28506, C07D28508, C07D28510, C07D28512, C07D23722, C07D23942, C07D24120, A61K 3141, A61K 3150, A61K 31505, A61K 31495
Patent
active
044056214
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
REFERENCES:
patent: 3225047 (1965-11-01), Partyka
patent: 3335142 (1967-08-01), Hardy et al.
patent: 3337552 (1967-08-01), Hirt
patent: 3622596 (1971-11-01), Fischer et al.
patent: 3646049 (1972-02-01), Hoft et al.
Durant Graham J.
Ganellin Charon R.
Daus Donald G.
Foggio Richard D.
Hendricks G.
Keps Joan S.
Lourie Alan D.
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