Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT...

Details Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT... Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT...

2011-03-29

2011-03-29

Jarrell, Noble (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S210190, C514S211010, C514S213010, C514S217030, C514S252130, C514S307000, C514S338000, C514S416000, C514S422000, C514S431000, C514S450000, C540S596000, C544S106000, C544S375000, C546S139000, C546S197000, C546S202000, C548S515000, C548S526000, C549S012000, C549S354000

Reexamination Certificate

active

07915249

ABSTRACT:
This invention concerns novel substituted heterocyclic tetracyclic tetrahydrofuran derivatives with binding affinities towards serotonin receptors, in particular 5-HT2Aand 5-HT2Creceptors, and towards dopamine receptors, in particular dopamine D2receptors and with norepinephrine reuptake inhibition properties, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production.The compounds according to the invention can be represented by general Formula (I)and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim1.

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