Heterocyclic sulfonamides

Details Heterocyclic sulfonamides Heterocyclic sulfonamides

2000-02-17

2002-07-09

Ford, John M. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

06417360

ABSTRACT:

BACKGROUND OF THE INVENTION
1. Field
The present invention relates to heterocyclic sulfonamides, methods for their manufacture, and their use as medicaments, especially for treating chronic heart failure.
2. Description
Sulfonamides are known inhibitors of endothelin receptors. See, for example, EP 0 713 875. There is a need for endothelin receptor inhibitors that have high antagonistic potency and achieve high plasma levels following oral administration.
SUMMARY OF THE INVENTION
The subject invention provides compounds of formula:
wherein
R
1
is pyridyl, pyridyl substituted with lower alkyl, pyridyl substituted with lower alkenyl, thiazolyl, thiazolyl substituted with lower alkyl, or thiazolyl substituted with lower alkenyl;
and pharmaceutically usable salts of such compounds.


REFERENCES:
patent: 5837708 (1998-11-01), Breu et al.
patent: 0 713 875 (1996-05-01), None
patent: 0 897 914 (1999-02-01), None
patent: WO 96 19459 (1996-06-01), None

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