Heterocyclic sulfonamide inhibitors of beta amyloid production

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S065000

Reexamination Certificate

active

07842718

ABSTRACT:
Compounds of Formula (I),wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's disease and Down's syndrome are described.

REFERENCES:
patent: 5464853 (1995-11-01), Chan et al.
patent: 5506243 (1996-04-01), Ando
patent: 5514691 (1996-05-01), Chan et al.
patent: 5561146 (1996-10-01), Kim
patent: 5571821 (1996-11-01), Chan
patent: 5591761 (1997-01-01), Chan et al.
patent: 5593846 (1997-01-01), Schenk
patent: 5594021 (1997-01-01), Chan
patent: 5624937 (1997-04-01), Reel
patent: 5703129 (1997-12-01), Felsenstein
patent: 5710153 (1998-01-01), Ohmoto
patent: 5852007 (1998-12-01), Chatterjee
patent: 5877193 (1999-03-01), Cesura
patent: 5981168 (1999-11-01), Reiner
patent: 6248775 (2001-06-01), Vazquez
patent: 6342610 (2002-01-01), Chan
patent: 6376523 (2002-04-01), Chan
patent: 6566536 (2003-05-01), Muller
patent: 6610734 (2003-08-01), Kreft et al.
patent: 6657070 (2003-12-01), Resnick
patent: 6878742 (2005-04-01), Kreft
patent: 7166622 (2007-01-01), Kreft
patent: 7300951 (2007-11-01), Kreft
patent: 7547725 (2009-06-01), Kreft
patent: 2009/0227667 (2009-09-01), Kreft
patent: 510700 (1992-10-01), None
patent: 0 652 009 (1995-05-01), None
patent: 652009 (1995-05-01), None
patent: 1172361 (1999-12-01), None
patent: 1088821 (2001-04-01), None
patent: 5-148233 (1993-06-01), None
patent: 07-048340 (1995-02-01), None
patent: 08-053492 (1996-02-01), None
patent: 09-136878 (1997-05-01), None
patent: 09-235276 (1997-09-01), None
patent: 10-067761 (1998-03-01), None
patent: 11-343279 (2002-01-01), None
patent: WO-95/29904 (1995-11-01), None
patent: WO-97/21690 (1997-06-01), None
patent: WO-97/24340 (1997-07-01), None
patent: WO-98/03166 (1998-01-01), None
patent: WO-98/16504 (1998-04-01), None
patent: WO-98/22104 (1998-05-01), None
patent: WO-98/22493 (1998-05-01), None
patent: WO-99/28316 (1999-06-01), None
patent: WO-99/62880 (1999-12-01), None
patent: WO-00/09107 (2000-02-01), None
patent: WO-00/50391 (2000-08-01), None
patent: WO-01/23379 (2001-04-01), None
patent: WO-01/27091 (2001-04-01), None
patent: WO-01/27108 (2001-04-01), None
patent: WO-02/057252 (2002-07-01), None
patent: WO-03/050062 (2003-06-01), None
patent: WO-03/050063 (2003-06-01), None
patent: WO-03/103660 (2003-12-01), None
Abstract of Japanese Patent No. JP-11-343279 Jan. 26, 2002.
Augelli-Szafran, “β-amyloid as a target for Alzheimer's Disease therapy”, Annual Reports in Medicinal Chemistry Ch. 3, Aug. 30, 1999 (34):21-30.
Dodart, “The β-amyloid precursor protein and its derivatives: From biology to learning and memory process”, Reviews in the Neurosciences 2000 11(2-3):75-93.
Esler, “Transition-state analogue inhibitors of β-secretase bind directly to presenilin-1”, Nature Cell Bio. Jul. 2000 2:428-434.
Findeis, “Modified-peptide inhibitors of amyloid β-peptide polymerization”, Biochem. May 25, 1999 38(21):6791-6800.
Ghosh, “Design of potent inhibitors for human brain memapsin 2 (β-secretase)”, J. Am. Chem. Soc., Apr. 12, 2000 122:3522-3523.
Goate, A., “Monogenetic determinants of Alzheimer's Disease: APP mutations”, Cell. Mol. Life Sci. Sep. 1998 54:897-901.
Han, “Total asymmetric synthesis of highly constrained amino acids isopropyl-2′, 6′-dimethyl-tyrosines”, Tetrahedron Letters, Jul. 21, 1997 38(29):5135-5138.
John, “Chapter 2. Alzheimer's Disease: Recent advances on the amyloid hypothesis”, Ann. Reports Med. Chem., Sep. 1997 32:11-20.
Larner, “Review—Central and peripheral nervous systems—Alzheimer's disease: Towards therapeutic manipulation of the amyloid precursor protein and amyloid peptides”, Exp. Opin. Ther. Patents, Oct. 1997 7(10):1115-1127.
Li, “Photoactivated β-secretase inhibitors directed to the active site covalently label presenilin 1”, Nature Jun. 2000 405:689-694.
Li, “The amyloid precursor protein of Alzheimer's Disease in human brain and blood”, J. of Leuko. Bio. Oct. 1999 66:567-574.
Moore, “Inhibition of β-amyloid formation as a therapeutic strategy”, Exp. Opin. Ther. Patents, Moore 1999 9(2):135-146.
Naslund, “Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline”, Jama, Mar. 2000, 283(12):1571-1577.
Rishton, “Fenchylamine sulfonamide inhibitors of amyloid peptide production by the β-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's Disease”, J. Med. Chem., Jun. 15, 2000, 43(12):2297-2299.
Sabbagh, “β-amyloid and treatment opportunities for Alzheimer's Disease”, Alzheimer's Disease Review 1997 3:1-19.
Sinha, “Purification and cloning of amyloid precursor protein β-secretase from human brain”, Nature Dec. 1999 402:537-540.
Skovronsky, “β-secretase revealed: Starting gate for race to novel therapies for Alzheimer's Disease”, TIPS May 2000 21:161-163.
Small, “Alzheimer's Disease and the amyloid protein: What is the role of amyloid?”, J. Neurochem. Aug. 1999 73(2):443-449.
Testa, “Prodrugs revisited: The “Ad Hoc” approach as a complement to ligand design”, Med. Res. Rev. May 1996 16(3):233-241.
Wagner, “Modulation of amyloid protein precursor processing as a means of retarding progression of Alzheimer's Disease”, J. Clin. Invest. Nov. 1999 104(10):1329-1332.
Wermuth, “Molecular variations based on isosteric replacements”, Prac. Med. Chem. Feb. 1996, pp. 203-237.
Wolfe, “A substrate-based difluoro ketone selectively inhibits Alzheimer's β-secretase activity”, J. Med. Chem. Jan. 1, 1998 41:6-9.
Mehta, “Techniques in Diagnostic Pathology”, vol. 2, Bullock et al., Eds., Academic Press: Boston, MA, 1991, pp. 99-112.
Office Action dated May 24, 2004 issued in U.S. Appl. No. 10/455,674.
Response to Office Action dated May 24, 2004 issued in U.S. Appl. No. 10/455,674.
Office Action dated Jun. 2, 2009 issued in U.S. Appl. No. 11/081,784.
Response to Office Action dated Jun. 2, 2009 issued in U.S. Appl. No. 11/081,784.
Office Action dated Dec. 1, 2008 issued in U.S. Appl. No. 11/081,784.
Response to Office Action dated Dec. 1, 2008 issued in U.S. Appl. No. 11/081,784.
Office Action dated Mar. 7, 2008 issued in U.S. Appl. No. 11/081,784.
Response to Office Action dated Mar. 7, 2008 issued in U.S. Appl. No. 11/081,784.
Office Action dated Jun. 13, 2007 issued in U.S. Appl. No. 11/081,784.
Response to Office Action dated Jun. 13, 2007 issued in U.S. Appl. No. 11/081,784.
Sugihara, English Abstract of JP 09-235276 (Sep. 9, 1997).
Cesura and Rover, English Abstract of JP 10-067761 (Mar. 10, 1998).
Omoto, English Abstract of JP 09-136878 (May 27, 1997).
Kim, English Abstract of JP 08-053492 (Feb. 27, 1996).
Ando, English Abstract of JP 07-048340 (Feb. 21, 1995).
Office Action issued in related Singapore Patent Application No. 200503628-0 (Oct. 3, 2008).
Office Action issued in corresponding Japanese Patent Application No. 557933/02 (Jun. 10, 2008).
International Search Report issued in International Patent Application No. PCT/US01/48375 (Aug. 2, 2002).
International Search Report issued in International Patent Application No. PCT/US03/18198 (Nov. 3, 2003).
International Search Report issued in International Patent Application No. PCT/US2004/009268 (Aug. 13, 2004).

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