Heterocyclic substituted pyrrolidine amide derivatives

Details Heterocyclic substituted pyrrolidine amide derivatives Heterocyclic substituted pyrrolidine amide derivatives

1997-12-15

1999-01-19

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546210, A61K 31445, C07D40114

Patent

active

058614176

ABSTRACT:
The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

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