Heterocyclic substituted piperazinone derivatives

Details Heterocyclic substituted piperazinone derivatives Heterocyclic substituted piperazinone derivatives

1997-06-19

1998-11-24

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544373, 548494, 548500, A61K 31495, C07D40306, C07D20920, C07D20924

Patent

active

058407260

ABSTRACT:
The present invention relates to substituted piperazinone derivatives (compounds of formula (1)) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).

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