Heterocyclic substituted piperazinone derivatives

Details Heterocyclic substituted piperazinone derivatives Heterocyclic substituted piperazinone derivatives

1998-04-27

1999-01-26

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548490, C07D20904, C07D20908

Patent

active

058640452

ABSTRACT:
The present invention relates to substituted piperazinone derivatives of formula (1) or stereoisomers, or pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis. The present invention also relates to intermediates useful in the preparation of compounds of formula (1).

REFERENCES:
Khandelwal et al., Chemical Abstracts, vol. 113, No. 78332, (1990).
Lewis et al., J. Med. Chem., 38, pp. 923-933 (Mar. 17, 1995).
Roussi et al., Biochemical and Biophysical Research Communications, 176, pp. 894-901 (1991).
Maggi et al., J. Auton. Pharmacol, 13, pp. 23-93 (1993).

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