Heterocyclic substituted cyclopentane compounds

Details Heterocyclic substituted cyclopentane compounds Heterocyclic substituted cyclopentane compounds

1996-06-04

2000-11-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544262, 544280, C07D48704, A61K 31505, A61K 3140, A61K 31415

Patent

active

061437492

ABSTRACT:
The present invention provides new heterocyclic substituted cyclopentane compounds that are useful in inhibiting adenosine kinase. The present invention also provides pharmaceutical compositions containing such compounds and methods of using such compounds for inhibiting adenosine kinase.

REFERENCES:
patent: 3296261 (1967-01-01), Partyka
patent: 3311628 (1967-03-01), Partyka
patent: 3551428 (1970-12-01), Druey
patent: 3682918 (1972-08-01), Druey et al.
S. Siddiqi et al., "Search for New Purine-and RiboseModified Adenosine Analogues as Selective Agonists and Atnagonists at Adenosine Receptors", J. Med. Chem., vol. 38, No. 7, (1995), pp. 1174-1188.
Miller, et al., Adenosine Kinase From Rabbit Liver; Journ of Biological Chemistry Issue of Apr. 10 pp. 2346-2353.
Pudlo, et al., Synthesis And Antiviral Activity Of Certain 4-And 4,5-Disubstituted 7-[(2-Hydroxyethosy) Methyl] Pyrrolo [2, 3-D] Pyrimidines, J. Med Chem1988 2086-2092.
Siddiqi, et al., Enantiospecific Synthesis of 5'Noraristeromycin and Its 7-Deaza Derivative and a Formal Synthesis of (-)-5'-Homoaristeromycin; Nucleosides &Nucleotides, 12(3&4), 267-278 (1993).
Siddiqi, et al., Enantiospecific Synthesis of The Fluoro and Epimeric Derivatives of 5'-Noraristeromycin, J. Chem Soc Chem Commun 1993 P 708.
Wolfe, et al., 4'-Modified Analogues of Aristeromycin and Neplanocin A: Synthesis and Inhibitory Activity Toward S-Adenosyl-L-Homocysteine Hydrolase, J. Med Chem 1992, 35, 1782-1791.
Patil, et al., Synthesis and Antiviral Properties of (.+-.) -5'-Noraristeromycin and Related Purine Carbocyclic Nucleosides. A New Lead For Anti-Human Cytomegalovirus Agent Design, J. Med. Chem. 1992, 35, 3372-3377.
Cottam, New Adenosine Kinase Inhibitors With Oral Antiinflammatory Activity, Drugs of the Future 1994, 19(5) :485-491.
Cottam, et al., New Adenosine Kinase Inhibitors With Oral Antiiflammatory Activity: Synthesis and Biological Evaluation, J. Med. Chem 1993, 36, 3424-3430.
Siddiqi. 3-deaza and 7-deaza-5'-noraisteromycin and their antiviral properties. J. Med. Chem. 38 1035-1038. 1995.
Siddiqi, S. M., et al., Bioorganic & Medicinal Chemistry Letters, vol. 3, No. 4, 1993 pp. 663-666.
Montgomery, et al., Journal of Medicianl Chemistry, vol. 10, No. 4, 1967, pp. 665-667.

Affiliated with

Also associated with

Rating

Heterocyclic substituted cyclopentane compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic substituted cyclopentane compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic substituted cyclopentane compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1641349