Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-09-09
McKane, Joseph K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514258, 544262, 544280, 544238, A61K 31505, C07D40702
Patent
active
056657218
ABSTRACT:
The present invention provides new heterocyclic substituted cyclopentane compounds that are useful in inhibiting adenosine kinase. The present invention also provides pharmaceutical compositions containing such compounds and methods of using such compounds for inhibiting adenosine kinase.
REFERENCES:
patent: 3296261 (1967-01-01), Partka et al.
Firestein et al., Protective effect of an Adenisine Kinase Inhibitor in Septic Shock, J. of Immunology, pp. 5853-5859. 1994.
Sawynok et al., The Role of Purines in Nociception, Neuroscience, vol. 32, No. 3, pp. 557-569. 1989.
Wolfe, et al., 4'-Modified Analogues of Aristeromycin and Neplanocin A: Synthesis and Inhibitory Activity Toward S-Adenosyl-L-Homocysteine Hydrolase, J. Med. Chen 1992, vol. 35, pp. 1782-1791.
Siddiqi, et al., Enantiospecific Synthesis of the Fluoro and Epimeric Derivatives of 5' Noraristeromycin, J. Chem. Soc., Chem. Commun., 1993, pp. 708-709.
Siddiqi, et al., Enantiospecific Synthesis of 5'-Noraristeromycin and Its 7-Deaza Derivative and A Formal Synthesis of (-)-5'-Homoaristeromycin, Nucleosides & Nucleotides, vol. 12(3&4), pp. 267-278 (1993).
Pudlo, et al., Synthesis and Antiviral Activity of Certain 4-and 4,5-Disubstituted 7-[2-Hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines, J. Med. Chem, 1988, vol. 31, No.11.
Miller, et al., Adenosine Kinase from Rabbit Liber, J. Bio. Chem, vol. 254, pp. 2346-2353, 1979.
Cottam, et al., New Adenosine Kinase Inhibitors with Oral Antiinflammatory Activity: Synthesis and Biological Evaluation, J. Med. Chem., 1993, vol. 36, No. 22, pp. 3424-3430.
Cottam, et al., New Adenosine Kinase Inhibitors with Oral Antiinflammatory Activity, Drugs of the Future, 1994, vol. 19(f); pp. 485-491.
Patel, et al., Synthesis and Antiviral Properties of (.+-.)-5'-Noraristeromycin and Related Purine Carbocyclic Nucleosides. A New Lead for Anti-Human Cytomegalovirus Agent Design, J. Med. Chem, 1992, vol. 35, pp. 3372-3377.
Siddiqi et al., 3-Deaza-and 7-Deaza-5'-noraristeromycin and Their Antiviral Properties, J. Med. Chem., 38, 1035-1038. 1995.
Bhagwat Shripad S.
Cowart Marlon Daniel
Abbott Laboratories
Browder Monte R.
McKane Joseph K.
Myers, Jr. Richard S.
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