Heterocyclic-substituted alkyl amide acat inhibitors

Details Heterocyclic-substituted alkyl amide acat inhibitors Heterocyclic-substituted alkyl amide acat inhibitors

1997-01-21

1997-12-02

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514381, 546276, 548253, A61K 3144, C07D40106

Patent

active

056936575

ABSTRACT:
Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 .dbd.R.sub.3 .dbd.H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.

REFERENCES:
patent: 3152140 (1964-10-01), Zeultz
patent: 3296304 (1967-01-01), Tilley et al.
patent: 3505349 (1970-04-01), Beaman et al.
patent: 4044144 (1977-08-01), Sellstedt et al.
patent: 4072498 (1978-02-01), Moon et al.
patent: 4160829 (1979-07-01), Heijboer et al.
patent: 4663323 (1987-05-01), Uchida et al.
patent: 4783487 (1988-11-01), Brune
patent: 4826868 (1989-05-01), Wachter et al.
patent: 5059614 (1991-10-01), Lepage et al.
patent: 5073566 (1991-12-01), Lifer et al.
patent: 5258397 (1993-11-01), Lepage et al.
patent: 5312726 (1994-05-01), Mihayashi et al.
Bull. Soc. Chim. Belg., vol. 96
.degree. Mar. 1987, pp. 225-228, Essassi et al.
J. Org. Chem., 1984, 49, 5247-5250, Chang-Kyu Kim, et al.
Chem. Abst., 98(19) 154905J, 1982, Ahmad et al.
Ahmad et al. Clinical Abstract, 98(19), 154905J. 1982.

Affiliated with

Also associated with

Rating

Heterocyclic-substituted alkyl amide acat inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic-substituted alkyl amide acat inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic-substituted alkyl amide acat inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-801640