Heterocyclic spiro-linked amidines, compositions and use thereof

Details Heterocyclic spiro-linked amidines, compositions and use thereof Heterocyclic spiro-linked amidines, compositions and use thereof

1980-02-21

1981-07-07

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242484, 42424855, 42424858, 424250, 424267, 424274, 544 6, 544 70, 544230, 546 15, 546 20, 2602457, 26032625, 26032638, 2603265D, 2603265L, 26032662, 2603268, 26032684, 26032685, 26032682, 2603269, A61K 3140, A61K 3154, C07D20722, C07D29500

Patent

active

042774705

ABSTRACT:
Heterocyclic, spiro-linked amidines of the formula I ##STR1## and their physiologically acceptable salts, in which (a) n is 1 or 2; (b) R.sup.1 and R.sup.2 are hydrogen or alkyl radicals which, together with the nitrogen atom, can form a 5-, 6- or 7-membered ring which can be substituted by C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.2 -alkoxy, hydroxyl or C.sub.1 -C.sub.4 -alkoxy-carbonyl groups and in which one of the carbon atoms can also be replaced by an oxygen, sulfur or nitrogen atom, it being possible for the nitrogen atom to be substituted by hydrogen, by the formyl group or by a phenyl radical, which can in turn be monosubstituted or polysubstituted by a C.sub.1 to C.sub.4 -alkyl group or an alkoxy, methylenedioxy, hydroxyl, halogen, nitro or amino group, or it being possible for the nitrogen atom to be substituted by a C.sub.1 -C.sub.4 -alkyl group, or in which R.sup.1 represents hydrogen and R.sup.2 represents a C.sub.5 -C.sub.8 -cycloalkyl radical which can be substituted by C.sub.1 -C.sub.4 -dialkylamino groups; (c) R.sup.3 is hydrogen or methyl and (d) R.sup. 4 denotes a phenyl radical which is optionally monosubstituted or polysubstituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, methylenedioxy, hydroxyl, halogen, cyano, nitro, trifluoromethyl, amino, C.sub.2 -C.sub.5 -acylamino or mono- or di-C.sub.1 -C.sub.4 -alkylamino groups, or a thiophene radical, their stereoisomers and optical isomers, processes for their preparation and antidepressive medicaments containing these compounds.

REFERENCES:
patent: 2931805 (1960-04-01), Weinstock

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