Heterocyclic spiro-compounds as aldosterone synthase inhibitors

Details Heterocyclic spiro-compounds as aldosterone synthase inhibitors Heterocyclic spiro-compounds as aldosterone synthase inhibitors

2006-05-30

2011-12-06

Dell, David K O (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S278000

Reexamination Certificate

active

08071773

ABSTRACT:
The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.

REFERENCES:
patent: 01/76574 (2001-10-01), None
patent: 2004/014914 (2004-02-01), None
patent: 2004/046145 (2004-06-01), None
Online: “Calculating the Degrees of Unsaturation From a Compound's Molecular Formula” from Organic Chemistry handouts Department of Chemistry Manhattanville College “http://faculty.mville.edu/ParikhS/courses/chm2001/docs/Handouts/Degree%20of%20unsaturation.pdf” accessed Nov. 20, 2010.
Browne et. al. “Fadrozole Hydrochloride: A Potent, Selective, Nonsteroidal Inhibitor of Aromatase for the Treatment of Estrogen-Dependent Disease” Journal of Medicinal Chemistry 1991, 34, 725-736.
Ulmschneider et. al. “Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase” Journal of Medicinal Chemistry 2005, 48, 1563-1575.
Ulmschneider et. al. “Synthesis and Evaluation of Imidazolylmethylenetetrahydronaphthalenes and Imidazolylmethyleneindanes: Potent Inhibitors of Aldosterone Synthase” Journal of Medicinal Chemistry 2005, 1796-1805.
International Search Report issued Aug. 10, 2006 in the International (PCT) Application PCT/EP2006/062696 of which the present application is the U.S. National Stage.

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