Heterocyclic spiro compounds and methods for preparing the same

Details Heterocyclic spiro compounds and methods for preparing the same Heterocyclic spiro compounds and methods for preparing the same

1990-01-25

1991-08-20

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 16, C07D49107

Patent

active

050415492

ABSTRACT:
Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## in which R.sup.1 to R.sub.3, R.sub.6, R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, --COOH, or ester, or ##STR3## R.sub.5 is halo, OH, SH, O alkyl, S alkyl, O acyl or S acyl, and Z.sub.1 and Z.sub.2 are O or S.
The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

REFERENCES:
patent: 4855290 (1989-08-01), Fisher
patent: 4981858 (1991-01-01), Fisher et al.

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