Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-05-03
2005-05-03
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S241000, C514S242000, C514S250000, C514S253090, C514S253100, C514S256000, C514S259410, C514S260100, C514S300000, C514S320000, C514S321000, C514S322000, C514S323000, C514S326000, C544S122000, C544S182000, C544S212000, C544S278000, C544S281000, C544S322000, C544S328000, C544S331000, C544S349000, C544S360000, C546S121000, C546S198000, C546S199000, C546S201000, C546S208000, C546S209000, C546S210000, C546S212000, C546S214000
Reexamination Certificate
active
06887870
ABSTRACT:
Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structurewherein n is 1 to 5; X is N or C—R5wherein R5is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R1, R2, R3and R4are as defined herein, and where X is N. R1is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.
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Ahmad Saleem
Atwal Karnail S.
Ngu Khehyong
O'Neil Steven V.
Weinstein David S.
Bristol--Myers Squibb Company
Raymond Richard L.
Rodney Burton
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