Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-09-27
2005-09-27
Stockton, Laura L. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S330000, C544S130000, C546S194000, C546S221000, C546S227000, C546S234000
Reexamination Certificate
active
06949545
ABSTRACT:
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following Formula (I):where R1, R2, R3, n, A, E, X, G, G′, M and Z have the meanings described in the specification and the claims, as well as optical isomers, diastereomers and enantiomers of Formula I, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions.
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Almstead Neil Gregory
De Biswanath
Hershberger Paul Mitchell
Laughlin Steven Karl
Natchus Michael George
McMahon Mary Pat
Paul Andrew A.
Stockton Laura L.
The Procter & Gamble & Company
Upite David V.
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