Heterocyclic retinoid compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S156000, C546S139000

Reexamination Certificate

active

07354931

ABSTRACT:
The current invention provide novel heterocyclic retinoid compounds, methods of treating or preventing chronic obstructive pulmonary disease, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of these disorders and methods for delivering formulations of these retinoids to a mammal having these disorders.

REFERENCES:
patent: 5716624 (1998-02-01), Bernardon
patent: 6046220 (2000-04-01), Bernardon
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Barnes, Novel Approaches and Targets for Treatment of Chronic Obstructive Pulmonary Disease, Am J Respir Crit Care Med vol. 160, pp. S72-S79, 1999.
Mao, A Pilot Study of All-trans-Retinoic Acid for the Treatment of Human Emphysema, Am J Respir Crit Care Med vol. 165. pp. 718-723, 2002.
Fujita, Retinoic acid fails to reverse emphysema in adult mouse models, Thorax 2004; 59:224-230.
. . . Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.

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