Drug – bio-affecting and body treating compositions – Nonspecific immunoeffector – per se ; or nonspecific... – Bacterium or component thereof or substance produced by said...
Patent
1981-08-06
1983-02-08
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Nonspecific immunoeffector, per se ; or nonspecific...
Bacterium or component thereof or substance produced by said...
542429, A61K 31557, C07D307935, A61K 3134
Patent
active
043729711
ABSTRACT:
Disclosed are new heterocyclic compounds, medicaments containing them (for oral or parenteral administration) and processes for the preparation and use of these heterocyclic compounds and medicaments. The new compounds which particularly act as inhibitors of blood platelet aggregation and as blood pressure lowering agents correspond to the general formula ##STR1## wherein R.sup.1 is hydrogen, a cation or the residue of an alcohol, R.sup.2 represents hydrogen or methyl, A is a member of the group consisting of the radicals --CH.sub.2 --CH.sub.2 --, (trans)--CH.dbd.CH-- and --C.tbd.C--, and wherein B represents an alkyl or a cycloalkyl radical. In these compounds the phenyl radical may be arranged with respect to the double bond in the E- and/or in the Z-configuration and at the carbon atom bearing the group R.sup.2 (and others) may exist RS- or S-configuration. The compounds of formula I are prepared in a manner known per se starting from derivatives of 3.alpha.,5.alpha.-dihydroxycyclopentane-1.alpha.-acetaldehyde .gamma.-lactol substituted accordingly and phosphonium salts of the formula ##STR2## wherein R.sup.6 represents hydrogen or alkyl and wherein Hal is chlorine, bromine or iodine.
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Michel Gudrun
Mueller Bernd
Seipp Ulrich
Vollenberg Werner
Dentz Bernard
Gruenenthal GmbH
Jiles Henry R.
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