Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-04-18
1992-11-17
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514210, 5142308, 5142315, 514252, 514255, 514315, 514326, 514345, 514397, 514 18, 540492, 544121, 544132, 544295, 544357, 544360, 544369, 544370, 544375, 544384, 544385, 544392, 544398, 544 95, 544 99, 546184, 546209, 546210, 546216, 548204, 548215, 548228, 548318, 548336, 548341, 548541, 530332, 560 45, 560 51, 562444, A61K 31495
Patent
active
051643880
ABSTRACT:
A renin inhibiting compound of the formula ##STR1## wherein X is N, O or CH; R.sub.1 is absent or a functional group; A and L are independently selected from absent, C.dbd.O, SO.sub.2 and CH.sub.2 ; D is C.dbd.O, SO.sub.2 or CH.sub.2 ; Y is N or CH; R.sub.2 is hydrogen, loweralkyl or substituted alkyl; Z is a functional group; R.sub.3 is loweralkyl or substituted alkyl; n is 0 or 1; and T is a mimic of the Leu-Val cleavage site of angiotensinogen; or a pharmaceutically acceptable salt, ester or prodrug thereof.
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Baker William R.
De Biswanath
Dellaria Joseph F.
Jae Hwan S.
Rosenberg Saul H.
Abbott Laboratories
Crowley Steven R.
Daus Donald G.
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