Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-04-17
1979-10-09
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546261, 546264, 546276, 424269, 548269, C07D21353, C07D24908, A61K 3144, A61K 3141
Patent
active
041706528
ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
REFERENCES:
patent: 4034101 (1977-07-01), Durant et al.
patent: 4049671 (1977-09-01), Durant et al.
patent: 4093621 (1978-06-01), Brown et al.
patent: 4098898 (1978-07-01), Durant et al.
patent: 4109003 (1978-08-01), Durant et al.
patent: 4120966 (1978-10-01), Brown et al.
Durant Graham J.
Ganellin Charon R.
Young Rodney C.
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Rotman Alan L.
Smith Kline & French Laboratories Limited
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