Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1995-08-25
1998-02-24
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
514335, 514346, 514 5, 514 22, 514261, 514291, 514292, C07D21184, C07D21381, C07D40112, A61K 3144
Patent
active
057212228
ABSTRACT:
The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
REFERENCES:
patent: 4880870 (1989-11-01), Trainor et al.
patent: 4910190 (1990-03-01), Bergson et al.
Bernstein Peter Robert
Shaw Andrew
Thomas Royston Martin
Veale Chris Allan
Warner Peter
Hohenschutz Liza D.
Rotman Alan L.
Zeneca Limited
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