Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-05-11
1992-11-17
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 19, 530331, 544297, 544322, 544333, 546293, 546306, 546332, 548159, 548188, 548217, 548228, 548233, 548237, C07D23708, C07D23906, C07K 508, A61K 3702
Patent
active
051643715
ABSTRACT:
The invention provides a series of novel heterocyclic ketones of formula I ##STR1## and pharmaceutically acceptable base-addition salts thereof, in which the values of R.sup.4, L, A, X and Q have the meanings defined in the following specification. The compounds of formula I are inhibitors of human leukocytic elastase. The invention also provides pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable base-addition salt thereof, and processes and intermediates for the manufacture of compounds of formula I.
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R. Graf, "Reactions with N-Carbonylsulfamoyl Chloride", Angew. Chem. Internat. Edit. (1968), 7, 172-182.
Chemical Abstracts, vol. 95, No. 25, 21st Dec. 1981, p. 223, abstract No. 216963a, Columbus, Ohio, U.S.; B. M. Ashe et al.: "Selective inhibition of human leukocyte elastase and bovine alpha-chymotrypsin by novel heterocycles", J. Biol. Chem. 1981, 256(22), 11603-6 *Abstract*.
Chemical Abstracts, vol. 97, No. 7, 16th Aug. 1982, p. 268, abstract No. 51652z, Columbus, Ohio, U.S.; T. Teshima et al.: "A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A, with substituted benzoxazinones, quinazolines, and anthranilates", J. Bio. Chem. 1982, 257(9), 5085-5091 *Abstract*.
Edwards Philip D.
Lewis Joseph J.
Perkins Charles W.
Trainor Diane A.
Wildonger Richard A.
Bond Robert T.
ICI Americas Inc.
Jackson Thomas E.
Miano Rosemay M.
Ward Edward C.
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