Heterocyclic inhibitors of serine proteases

Details Heterocyclic inhibitors of serine proteases Heterocyclic inhibitors of serine proteases

1984-08-20

1986-06-24

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

435184, 514431, 514460, A61K 3135, C12N 999

Patent

active

045968225

ABSTRACT:
Certain novel heterocyclic compounds, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like, elastase-like, and trypsin-like specificity and in the treatment of diseases such as emphysema which involve tissue proteolysis.

REFERENCES:
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Davies and Poole, J. Chem. Soc., pp. 1616-1629 (1928).
Milevskaya, Belinskaya, and Yagupol'skii, Zhur. Org. Khim 9, pp. 2145-2149 (1973).
Tirodkar and Usgaonkar, Ind. J. Chem. 7, pp. 1114-1116 (1969).
Choksey and Usgaonkar, Ind. J. Chem. 14B, pp. 496-598 (1976).
Knott, J. Chem. Soc., pp. 402-410 (1963).
Powers, Ad. in Chem., 198, pp. 347-367 (1982).

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