Heterocyclic inhibitors of serine proteases

Details Heterocyclic inhibitors of serine proteases Heterocyclic inhibitors of serine proteases

1986-03-26

1989-07-11

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

5142305, 514259, 514309, 514307, 514432, 514460, 514456, 435213, 435218, 435219, 544286, 544283, 544 92, 544 93, 546141, 546142, C07D26512, C07D23972, C07D21722, C12N 999

Patent

active

048472026

ABSTRACT:
Certain novel heterocyclic compounds, aromatic thioesters, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity and in the treatment of diseases such as emphysema which involve tissue proteolysis.

REFERENCES:
patent: 3772304 (1973-11-01), Grethe et al.
patent: 4465687 (1984-08-01), Doherty et al.
patent: 4469885 (1984-09-01), Mueller et al.
patent: 4493839 (1985-01-01), Doherty et al.
Kleinerman et al., Am. Rev. Respir. Dis., 1981, pp. 714-717.

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