Heterocyclic inhibitors of microsomal triglyceride transfer prot

Details Heterocyclic inhibitors of microsomal triglyceride transfer prot Heterocyclic inhibitors of microsomal triglyceride transfer prot

1997-12-08

1999-10-12

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142368, 514256, 514318, 514319, 514320, 514321, 514322, 514324, 514326, 514331, 514397, 514422, 514429, 514325, 544 88, 544130, 544287, 544360, 544405, 546200, 546202, 546203, 546208, 546 22, 546189, 546193, 546198, 548119, 5483121, 5483381, A61K 31445, A61K 3147, A61K 31495, C07D21158, C07D23378, C07D40112, C07D47110

Patent

active

059655771

ABSTRACT:
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof, or prodrug esters thereof,

REFERENCES:
patent: 3754001 (1973-08-01), Timmer et al.
patent: 5712279 (1998-01-01), Biller et al.
patent: 5780465 (1998-07-01), Markley et al.
U.S. Application No. 08/842,132 filed Apr. 23, 1997.
U.S. Application No. 08/847,775, filed Apr. 23, 1997.

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