Heterocyclic inhibitors of MEK and methods of use thereof

Details Heterocyclic inhibitors of MEK and methods of use thereof Heterocyclic inhibitors of MEK and methods of use thereof

2004-11-18

2009-08-18

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...

C514S301000, C514S302000, C514S303000, C546S114000, C546S115000, C546S117000

Reexamination Certificate

active

07576072

ABSTRACT:
Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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