Heterocyclic inhibitors of MEK and methods of use thereof

Details Heterocyclic inhibitors of MEK and methods of use thereof Heterocyclic inhibitors of MEK and methods of use thereof

2007-06-12

2007-06-12

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S362000, C546S121000

Reexamination Certificate

active

10929295

ABSTRACT:
Disclosed are compounds of the Formulaand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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