Heterocyclic inhibitors of MEK and methods of use thereof

Details Heterocyclic inhibitors of MEK and methods of use thereof Heterocyclic inhibitors of MEK and methods of use thereof

2007-09-18

2007-09-18

McKane, Joseph K. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S121000

Reexamination Certificate

active

11410343

ABSTRACT:
Disclosed are compounds of the Formula Vand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9, R10, R11and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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Rosenberger, et al.“Macrophages Inhibit Salmonella Typhimurium Replication through MEK/ERK Kinase and Phagocyte NADPH Oxidase Activities”; J. Bio. Chem. May 2002; pp. 18753-18762; vol. 277, No. 21; US.

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