Heterocyclic inhibitors of MEK and methods of use thereof

Details Heterocyclic inhibitors of MEK and methods of use thereof Heterocyclic inhibitors of MEK and methods of use thereof

2006-12-05

2006-12-05

Shameem, Golam M. M. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S241000

Reexamination Certificate

active

07144907

ABSTRACT:
Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9and R10, W and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

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