Heterocyclic inhibitors of ERK2 and uses thereof

Details Heterocyclic inhibitors of ERK2 and uses thereof Heterocyclic inhibitors of ERK2 and uses thereof

2007-08-07

2007-08-07

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S340000, C514S341000, C514S342000, C514S343000, C546S270400, C546S271100, C546S271400, C546S272100, C546S272400, C546S274100, C546S275400, C546S279100, C546S280400, C546S284700

Reexamination Certificate

active

10770814

ABSTRACT:
Described herein are compounds that are useful as protein kinase inhibitors having the formula:wherein Z1and Z2are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

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