Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-02-15
2005-02-15
Riley, Jezia (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C544S001000
Reexamination Certificate
active
06855503
ABSTRACT:
Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additionally, these FRET cassettes/terminators, of the present invention, derived from different classes of heterocyclic systems have high potential to be used for general labelling of biological molecules to generate highly sensitized signals. Their preparation, energy transfer efficiency, and use as labels, specifically, in DNA sequencing reactions is disclosed.
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Lasken et al. Proc. Natl. Acad. Sci. USA, vol. 82, pp. 1301-1305, Mar. 1985.
Kumar Shiv
Nampalli Satyam
Rao Sudhakar
Zhang Weihong
Amersham Biosciences Corp
Ji Yonggang
Riley Jezia
Ronning, Jr. Royal N.
Ryan Stephen G.
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