Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-10-05
1999-10-19
Huang, Evelyn Mei
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 82, A61K 3144, C07D47114
Patent
active
059689463
ABSTRACT:
This invention relates to a series of substituted 3-oxo-pyrrolo[1,2-a]imidazopyridine derivatives of the formula 1 ##STR1## where X.sub.1 -X.sub.4, R.sub.1, R.sub.2 and Ar are defined herein. In addition the invention relates to pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are ligands for the benzodiazepine site on the GABA-A receptor and display anxiolytic and anticonvulsant activity in animal models.
REFERENCES:
patent: 5639760 (1997-06-01), Maryanoff
patent: 5817668 (1998-10-01), Reitz
Maryanoff Bruce E.
McComsey David
McNally James J.
Nortey Samuel O.
Reitz Allen B.
Huang Evelyn Mei
Ortho-McNeil Pharmaceutical , Inc.
Palo Ralph R.
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